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[The directed modification of Escherichia coli MG1655 to obtain histidine-producing mutants].

Prikladnaia biokhimiia i mikrobiologiia - 1 Jan 2000

Doroshenko V G, Lobanov A O, Fedorina E A

Abstract excerpt

Strain MG 1655+hisGr hisL'-Delta, purR, which produces histidine with a weight yield of approximately 12% from glucose, was constructed through directed chromosomal modifications of the laboratory Escherichia coli strain MG 1655+, which has a known genome sequence. A feedback-resistant ATP-phosphoribosyl transferase encoded by the mutant hisGr (E271 K) was the main determinant of histidine production. A further...

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PMID: 23795473
DOI: 10.7868/s0555109913020037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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