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Article

<i>ATF3</i>, an adaptive-response gene, enhances TGFβ signaling and cancer-initiating cell features in breast cancer cells

7 Oct 2010

Abstract excerpt

The activating transcription factor 3 (ATF3) gene is induced by a variety of signals, including many of those encountered by cancer cells. We present evidence that ATF3 is induced by TGFβ in the MCF10CA1a breast cancer cells and plays an integral role for TGFβ to upregulate its target genes snail, slug and twist, and to enhance cell motility. Furthermore, ATF3 upregulates the expression of the TGFb gene itself,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20930144
DOI: 10.1242/jcs.064915

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