Article
Expression of cilium-associated genes defines novel molecular subtypes of idiopathic pulmonary fibrosis.
Thorax - 1 Dec 2013
Yang Ivana V, Coldren Christopher D, Leach Sonia M, Seibold Max A, Murphy Elissa, Lin Jia, Rosen Rachel, Neidermyer Amanda J, McKean David F, Groshong Steve D, Cool Carlyne, Cosgrove Gregory P, Lynch David A, Brown Kevin K, Schwarz Marvin I, Fingerlin Tasha E, Schwartz David A
Abstract excerpt
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is an untreatable lung disease with a median survival of only 3-5 years that is diagnosed using a combination of clinical, radiographic and pathologic criteria. Histologically, IPF is characterised by usual interstitial pneumonia (UIP), a fibrosing interstitial pneumonia with a pattern of heterogeneous, subpleural regions of fibrotic and remodelled lung. We...
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