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Article

An Escherichia coli effector protein promotes host mutation via depletion of DNA mismatch repair proteins.

mBio - 18 Jun 2013

Maddocks Oliver David Kenneth, Scanlon Karen Mary, Donnenberg Michael S

Abstract excerpt

Enteropathogenic Escherichia coli (EPEC) is an attaching and effacing (A/E) human pathogen that causes diarrhea during acute infection, and it can also sustain asymptomatic colonization. A/E E. coli depletes host cell DNA mismatch repair (MMR) proteins in colonic cell lines and has been detected in colorectal cancer (CRC) patients. However, until now, a direct link between infection and host mutagenesis has not...

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Identifiers

PMID: 23781066
DOI: 10.1128/mBio.00152-13
PMCID: PMC3684829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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