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The EspF N-Terminal of Enterohemorrhagic Escherichia coli O157:H7 EDL933w Imparts Stronger Toxicity Effects on HT-29 Cells than the C-Terminal.

Frontiers in cellular and infection microbiology - 1 Jan 2017

Wang Xiangyu, Du Yanli, Hua Ying, Fu Muqing, Niu Cong, Zhang Bao, Zhao Wei, Zhang Qiwei, Wan Chengsong

Abstract excerpt

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 EspF is an important multifunctional protein that destroys the tight junctions of intestinal epithelial cells and promotes host cell apoptosis. However, its molecular mechanism remains elusive. We knocked out the espF sequence (747 bp, ΔespF), N-terminal sequence (219 bp, ΔespFN ), and C-terminal sequence (528 bp, ΔespFC ) separately using the pKD46-mediated λ Red...

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Identifiers

PMID: 28983470
DOI: 10.3389/fcimb.2017.00410
PMCID: PMC5613159

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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