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Modeling the mouse lymphoma forward mutational assay: the Gene-Tox program database.

Mutation research - 16 Feb 2000

Grant S G, Zhang Y P, Klopman G, Rosenkranz H S

Abstract excerpt

An SAR model of the induction of mutations at the tk(+/-) locus of L5178Y mouse lymphoma cells (MLA, for mouse lymphoma assay) was derived based upon a re-evaluation of experimental results reported by a Gene-Tox (GT) working group [A.D. Mitchell, A.E. Auletta, D. Clive, P.E. Kirby, M.M. Moore, B.C. Myhr, The L5178Y/tk(+/-) mouse lymphoma specific gene and chromosomal mutation assay. A phase III report of the...

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PMID: 10708987
DOI: 10.1016/s1383-5718(99)00186-2

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