Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased anxiety in offspring reared by circadian Clock mutant mice.

PloS one - 1 Jan 2013

Koizumi Hiroko, Kurabayashi Nobuhiro, Watanabe Yuto, Sanada Kamon

Abstract excerpt

The maternal care that offspring receive from their mothers early in life influences the offspring's development of emotional behavior in adulthood. Here we found that offspring reared by circadian clock-impaired mice show elevated anxiety-related behavior. Clock mutant mice harboring a mutation in Clock, a key component of the molecular circadian clock, display altered daily patterns of nursing behavior that is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety
Share to Brain
Share to CLOCK Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Maternal Behavior

Share to Mutation

Share to Serotonin

Source

Open in PubMed Open full text

Identifiers

PMID: 23776596
DOI: 10.1371/journal.pone.0066021
PMCID: PMC3680406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased anxiety in offspring reared by circadian Clock mutant mice.PMID 23776596Read ↗

Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice.Semantic proximity Read ↗

Unexpected effects of early-life adversity and social enrichment on the anxiety profile of mice varying in serotonin transporter genotype.Semantic proximity Read ↗

A novel murine model to study the impact of maternal depression and antidepressant treatment on biobehavioral functions in the offspringSemantic proximity Read ↗

Using Animal Models to Disentangle the Role of Genetic, Epigenetic, and Environmental Influences on Behavioral Outcomes Associated with Maternal Anxiety and DepressionSemantic proximity Read ↗

The impact of prenatal circadian rhythm disruption on pregnancy outcomes and long-term metabolic health of mice progeny.Semantic proximity Read ↗

Circadian alignment in a foster mother improves the offspring's pathological phenotype.Semantic proximity Read ↗

Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience.Semantic proximity Read ↗

Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors.Semantic proximity Read ↗

Maternal care of heterozygous Dopamine Receptor D4 knockout mice: Differential susceptibility to early-life rearing conditionsSemantic proximity Read ↗

Maternal care of heterozygous dopamine receptor D4 knockout mice: Differential susceptibility to early-life rearing conditions.Semantic proximity Read ↗

Circadian Clock mutation in dams disrupts nursing behavior and growth of pups.Semantic proximity Read ↗

An epigenomic shift in amygdala marks the transition to maternal behaviors in alloparenting virgin female miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.