Article
A super-family of transcriptional activators regulates bacteriophage packaging and lysis in Gram-positive bacteria.
Nucleic acids research - 1 Aug 2013
Quiles-Puchalt Nuria, Tormo-Más María Ángeles, Campoy Susana, Toledo-Arana Alejandro, Monedero Vicente, Lasa Iñigo, Novick Richard P, Christie Gail E, Penadés José R
Abstract excerpt
The propagation of bacteriophages and other mobile genetic elements requires exploitation of the phage mechanisms involved in virion assembly and DNA packaging. Here, we identified and characterized four different families of phage-encoded proteins that function as activators required for transcription of the late operons (morphogenetic and lysis genes) in a large group of phages infecting Gram-positive bacteria....
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