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Article

Phage portal proteins counteract stringent-response-mediated restriction.

Nature communications - 11 Jul 2026

Kronborg Kristina, Wang Luokai, Schicketanz Muriel Leandra, Gerdes Kenn, Zhang Yong Everett

Abstract excerpt

Bacteria restrict viral replication not only through dedicated defense systems but also by entering physiological states that limit cellular resources, yet how phages overcome such host-imposed barriers remains unclear. The stringent response, driven by the alarmone nucleotides ppGpp and pppGpp, can impose a growth-restrictive state that hinders phage infection in specific phage-host contexts. Here, we show that...

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PMID: 42436197
DOI: 10.1038/s41467-026-75532-5
PMCID: PMC13483052

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