Article
The bacteriophage T4 rapid-lysis genes and their mutational proclivities.
Journal of bacteriology - 1 Jul 2011
Burch Lauranell H, Zhang Leilei, Chao Frank G, Xu Hong, Drake John W
Abstract excerpt
Like most phages with double-stranded DNA, phage T4 exits the infected host cell by a lytic process requiring, at a minimum, an endolysin and a holin. Unlike most phages, T4 can sense superinfection (which signals the depletion of uninfected host cells) and responds by delaying lysis and achieving an order-of-magnitude increase in burst size using a mechanism called lysis inhibition (LIN). T4 r mutants, which are...
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