Article
Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR.
Nature - 18 Jul 2013
Ebert Daniel H, Gabel Harrison W, Robinson Nathaniel D, Kastan Nathaniel R, Hu Linda S, Cohen Sonia, Navarro Adrija J, Lyst Matthew J, Ekiert Robert, Bird Adrian P, Greenberg Michael E
Abstract excerpt
Rett syndrome (RTT) is an X-linked human neurodevelopmental disorder with features of autism and severe neurological dysfunction in females. RTT is caused by mutations in methyl-CpG-binding protein 2 (MeCP2), a nuclear protein that, in neurons, regulates transcription, is expressed at high levels similar to that of histones, and binds to methylated cytosines broadly across the genome. By phosphotryptic mapping,...
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