Article

Newly Identified Breast Luminal Progenitor and Gestational Stem Cell Populations Likely Give Rise to HER2-Overexpressing and Basal-Like Breast Cancers

2022-03-21

Abstract excerpt

Breast Cancer (BrC) is a common malignancy with genetically diverse subtypes. There is evidence that specific BrC subtypes originate from particular normal mammary cell populations. However, the cell populations that give rise to most BrC subtypes are unidentified. Several human breast scRNAseq datasets are available. In this research, we utilized a robust human scRNAseq dataset to identify population-specific mar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0cef2302-4033-5c93-85bc-0a4d73c5e20e
DOI: 10.21203/rs.3.rs-1449625/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Newly Identified Breast Luminal Progenitor and Gestational Stem Cell Populations Likely Give Rise to HER2-Overexpressing and Basal-Like Breast CancersDOI 10.21203/rs.3.rs-1449625/v1Read

Breast Cancer Stem Cells: Biomarkers, Identification and Isolation Methods, Regulating Mechanisms, Cellular Origin, and BeyondSemantic proximity Read

Single-cell transcriptomics reveal the heterogeneity and dynamic of cancer stem-like cells during breast tumor progressionSemantic proximity Read

Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypothesesSemantic proximity Read

A single-cell atlas of the healthy breast tissues reveals clinically relevant clusters of breast epithelial cellsSemantic proximity Read

ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype.Semantic proximity Read

Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapySemantic proximity Read

Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesisSemantic proximity Read

Stem Cells and Cellular Origins of Breast Cancer: Updates in the Rationale, Controversies, and Therapeutic ImplicationsSemantic proximity Read

Mammary gland stem cells and their application in breast cancer.Semantic proximity Read

A single cell atlas of the healthy breast tissues reveal clinically relevant clusters of breast epithelial cellsSemantic proximity Read

Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversitySemantic proximity Read

A spatially resolved single cell genomic atlas of the adult human breastSemantic proximity Read