Article
The trehalose pathway regulates mitochondrial respiratory chain content through hexokinase 2 and cAMP in Saccharomyces cerevisiae.
The Journal of biological chemistry - 2 Oct 2009
Noubhani Abdelmajid, Bunoust Odile, Bonini Beatriz Monge, Thevelein Johan M, Devin Anne, Rigoulet Michel
Abstract excerpt
In yeast, trehalose is synthesized by a multimeric enzymatic complex: TPS1 encodes trehalose 6-phosphate synthase, which belongs to a complex that is composed of at least three other subunits, including trehalose 6-phosphate phosphatase Tps2 and the redundant regulatory subunits Tps3 and Tsl1. The product of the TPS1 gene plays an essential role in the control of the glycolytic pathway by restricting the influx...
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