Article
Disruption of the Candida albicans TPS1 gene encoding trehalose-6-phosphate synthase impairs formation of hyphae and decreases infectivity.
Journal of bacteriology - 1 Aug 1998
Zaragoza O, Blazquez M A, Gancedo C
Abstract excerpt
The TPS1 gene from Candida albicans, which encodes trehalose-6-phosphate synthase, has been cloned by functional complementation of a tps1 mutant from Saccharomyces cerevisiae. In contrast with the wild-type strain, the double tps1/tps1 disruptant did not accumulate trehalose at stationary phase...
Topics
- Animals
- Bacteria
- Base Sequence
- Candida albicans
- Candidiasis
- Cloning, Molecular
- Evolution, Molecular
- Fructose
- Gene Deletion
- Genes, Fungal
- Genetic Complementation Test
- Genotype
- Glucose
- Glucosyltransferases
- Male
- Mice
- Molecular Sequence Data
- Mutagenesis, Site-Directed