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Article

Disruption of the Candida albicans TPS1 gene encoding trehalose-6-phosphate synthase impairs formation of hyphae and decreases infectivity.

Journal of bacteriology - 1 Aug 1998

Zaragoza O, Blazquez M A, Gancedo C

Abstract excerpt

The TPS1 gene from Candida albicans, which encodes trehalose-6-phosphate synthase, has been cloned by functional complementation of a tps1 mutant from Saccharomyces cerevisiae. In contrast with the wild-type strain, the double tps1/tps1 disruptant did not accumulate trehalose at stationary phase or after heat shock. Growth of the tps1/tps1 disruptant at 30 degreesC was indistinguishable from that of the wild...

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Identifiers

PMID: 9683476
DOI: 10.1128/JB.180.15.3809-3815.1998
PMCID: PMC107363

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Source receipt: pubmed, retrieved 7 Sept 2026.

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