Article
Expression of escherichia coli otsA in a Saccharomyces cerevisiae tps1 mutant restores trehalose 6-phosphate levels and partly restores growth and fermentation with glucose and control of glucose influx into glycolysis.
The Biochemical journal - 15 Aug 2000
Bonini B M, Van Vaeck C, Larsson C, Gustafsson L, Ma P, Winderickx J, Van Dijck P, Thevelein J M
Abstract excerpt
The TPS1 gene, encoding trehalose-6-phosphate synthase (TPS), exerts an essential control on the influx of glucose into glycolysis in the yeast Saccharomyces cerevisiae. The deletion of TPS1 causes an inability to grow on glucose because of a hyperaccumulation of sugar phosphates and depletion of ATP and phosphate. We show that expression of the Escherichia coli homologue, otsA, in a yeast tps1 mutant results in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.