Article
Chick embryo extract demethylates tumor suppressor genes in osteosarcoma cells.
Clinical orthopaedics and related research - 1 Mar 2014
Mu Xiaodong, Sultankulov Bolat, Agarwal Riddhima, Mahjoub Adel, Schott Trevor, Greco Nicholas, Huard Johnny, Weiss Kurt
Abstract excerpt
BACKGROUND: Epigenetics is the study of changes in gene expression or cellular phenotype caused by mechanisms other than changes in the underlying DNA sequence. It is widely accepted that cancer has genetic and epigenetic origins. The idea of epigenetic reprogramming of cancer cells by an embryonic microenvironment possesses potential interest from the prospect of both basic science and potential therapeutic...
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