Optimization of the chicken chorioallantoic membrane assay as reliable in vivo model for the analysis of osteosarcoma

Abstract excerpt

Survival rates of osteosarcoma patients could not be significantly improved by conventional chemotherapeutic treatment regimens since the introduction of high-dose chemotherapy 35 years ago. Therefore, there is a strong clinical need for new therapeutic targets and personalized treatment strategies, requiring reliable in vivo model systems for the identification and testing of potential new treatment approaches....

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