Article
Microenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors.
BMC cancer - 1 Sept 2010
Hamm Christopher A, Stevens Jeff W, Xie Hehuang, Vanin Elio F, Morcuende Jose A, Abdulkawy Hakeem, Seftor Elisabeth A, Sredni Simone T, Bischof Jared M, Wang Deli, Malchenko Sergey, Bonaldo Maria de Fatima, Casavant Thomas L, Hendrix Mary J C, Soares Marcelo B
Abstract excerpt
BACKGROUND: Chondrosarcomas are malignant cartilage tumors that do not respond to traditional chemotherapy or radiation. The 5-year survival rate of histologic grade III chondrosarcoma is less than 30%. An animal model of chondrosarcoma has been established--namely, the Swarm Rat Chondrosarcoma (SRC)--and shown to resemble the human disease. Previous studies with this model revealed that tumor microenvironment...
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