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Epigenetic alterations and microRNAs

1 Jun 2013

Abstract excerpt

The term epigenetics refers to the heritable changes in gene expression that do not represent changes in DNA sequence. DNA methylation and histone modification are the best studied epigenetic mechanisms. However, microRNAs, which affect gene expression at the posttranscriptional level, should be considered as members of the epigenetic machinery too. Myelodysplastic syndromes (MDS) are clone disorders of the...

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PMID: 23760524
DOI: 10.4161/epi.24897

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