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Article

Structural insight into Caenorhabditis elegans sex-determining protein FEM-2.

The Journal of biological chemistry - 26 Jul 2013

Zhang Yi, Zhao Haifeng, Wang Jia, Ge Jingpeng, Li Yang, Gu Jinke, Li Peng, Feng Yue, Yang Maojun

Abstract excerpt

In the nematode Caenorhabditis elegans, fem-1, fem-2, and fem-3 play crucial roles in male sexual development. Among these three genes, fem-2 encodes a PP2C (serine/threonine phosphatase type 2C)-like protein, whose activity promotes the development of masculinity. Different from the canonical PP2Cs, FEM-2 consists of an additional N-terminal domain (NTD) apart from its C-terminal catalytic domain. Interestingly,...

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PMID: 23760267
DOI: 10.1074/jbc.M113.464339
PMCID: PMC3724659

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