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Article

Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans.

ACS synthetic biology - 15 Nov 2013

Yin Wen-Bing, Chooi Yit Heng, Smith Adam R, Cacho Ralph A, Hu Youcai, White Theodore C, Tang Yi

Abstract excerpt

Dermatophytes belonging to the Trichophyton and Arthroderma genera cause skin infections in humans and animals. From genome sequencing data, we mined a conserved gene cluster among dermatophytes that are homologous to one that produces an immunosuppressive polyketide in Aspergillus fumigatus. Using a recombination-based cloning strategy in yeast, we constructed fungal heterologous expression vectors that encode...

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Identifiers

PMID: 23758576
DOI: 10.1021/sb400048b
PMCID: PMC3795930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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