Article
Diversity of type I polyketide synthase genes in the wood-decay fungus Xylaria sp. BCC 1067.
FEMS microbiology letters - 1 Oct 2005
Amnuaykanjanasin Alongkorn, Punya Juntira, Paungmoung Porntip, Rungrod Amporn, Tachaleat Anuwat, Pongpattanakitshote Somchai, Cheevadhanarak Supapon, Tanticharoen Morakot
Abstract excerpt
Fungal type I polyketide (PK) compounds are highly valuable for medical treatment and extremely diverse in structure, partly because of the enzymatic activities of reducing domains in polyketide synthases (PKSs). We have cloned several PKS genes from the fungus Xylaria sp. BCC 1067, which produces two polyketides: depudecin (reduced PK) and 19,20-epoxycytochalasin Q (PK-nonribosomal peptide (NRP) hybrid). Two new...
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