Article
[Association between 242C > T polymorphism of NADPH oxidase p22phox gene (CYBA) and longevity in Russian population].
Genetika - 1 Mar 2013
Zheĭkova T V, Golubenko M V, Buĭkin S V, Botkina O Iu, Tsimbaliuk I V, Maksimov V N, Voevoda M I, Puzyrev
Abstract excerpt
Life span depends on many factors, including the level of reactive oxygen species, like superoxide radical. Superoxide radical is produced from oxygen in the course of the oxidation of NADPH to NADP+. The process is catalyzed by NADPH oxidase. In this study, genotype and allele distributions of the C242T polymorphism in the CYBA gene, which encodes the alpha subunit ofNADPH oxidase (p22phox), were examined in the...
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