Article
Effects of sample size on differential gene expression, rank order and prediction accuracy of a gene signature.
PloS one - 1 Jan 2013
Stretch Cynthia, Khan Sheehan, Asgarian Nasimeh, Eisner Roman, Vaisipour Saman, Damaraju Sambasivarao, Graham Kathryn, Bathe Oliver F, Steed Helen, Greiner Russell, Baracos Vickie E
Abstract excerpt
Top differentially expressed gene lists are often inconsistent between studies and it has been suggested that small sample sizes contribute to lack of reproducibility and poor prediction accuracy in discriminative models. We considered sex differences (69♂, 65 ♀) in 134 human skeletal muscle biopsies using DNA microarray. The full dataset and subsamples (n = 10 (5 ♂, 5 ♀) to n = 120 (60 ♂, 60 ♀)) thereof were...
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