Article
Haemodynamically dependent valvulogenesis of zebrafish heart is mediated by flow-dependent expression of miR-21.
Nature communications - 1 Jan 2013
Banjo Toshihiro, Grajcarek Janin, Yoshino Daisuke, Osada Hideto, Miyasaka Kota Y, Kida Yasuyuki S, Ueki Yosuke, Nagayama Kazuaki, Kawakami Koichi, Matsumoto Takeo, Sato Masaaki, Ogura Toshihiko
Abstract excerpt
Heartbeat is required for normal development of the heart, and perturbation of intracardiac flow leads to morphological defects resembling congenital heart diseases. These observations implicate intracardiac haemodynamics in cardiogenesis, but the signalling cascades connecting physical forces, gene expression and morphogenesis are largely unknown. Here we use a zebrafish model to show that the microRNA, miR-21,...
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