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Primary cilia mediate Klf2-dependant Notch activation in regenerating heart

5 Apr 2020

Abstract excerpt

Unlike adult mammalian heart, zebrafish heart has a remarkable capacity to regenerate after injury. Previous study has shown Notch signaling activation in the endocardium is essential for regeneration of the myocardium and this activation is mediated by hemodynamic alteration after injury, however, the molecular mechanism has not been fully explored. In this study we demonstrated that blood flow change could be...

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PMID: 32249387
DOI: 10.1007/s13238-020-00695-w

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