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Article

A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes.

Nature cell biology - 1 Jul 2013

Yin Zheng, Sadok Amine, Sailem Heba, McCarthy Afshan, Xia Xiaofeng, Li Fuhai, Garcia Mar Arias, Evans Louise, Barr Alexis R, Perrimon Norbert, Marshall Christopher J, Wong Stephen T C, Bakal Chris

Abstract excerpt

The way in which cells adopt different morphologies is not fully understood. Cell shape could be a continuous variable or restricted to a set of discrete forms. We developed quantitative methods to describe cell shape and show that Drosophila haemocytes in culture are a heterogeneous mixture of five discrete morphologies. In an RNAi screen of genes affecting the morphological complexity of heterogeneous cell...

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PMID: 23748611
DOI: 10.1038/ncb2764
PMCID: PMC3712499

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PTEN

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