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Article

The Functional Unit of Neisseria meningitidis 3-Deoxy-ᴅ-Arabino-Heptulosonate 7-Phosphate Synthase Is Dimeric.

PloS one - 1 Jan 2016

Cross Penelope J, Heyes Logan C, Zhang Shiwen, Nazmi Ali Reza, Parker Emily J

Abstract excerpt

Neisseria meningitidis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (NmeDAH7PS) adopts a homotetrameric structure consisting of an extensive and a less extensive interface. Perturbation of the less extensive interface through a single mutation of a salt bridge (Arg126-Glu27) formed at the tetramer interface of all chains resulted in a dimeric DAH7PS in solution, as determined by small angle X-ray...

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PMID: 26828675
DOI: 10.1371/journal.pone.0145187
PMCID: PMC4735112

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