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Article

Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase.

Biochemistry - 17 Jul 2012

Barta Michael L, McWhorter William J, Miziorko Henry M, Geisbrecht Brian V

Abstract excerpt

Mevalonate diphosphate decarboxylase (MDD) catalyzes the final step of the mevalonate pathway, the Mg(2+)-ATP dependent decarboxylation of mevalonate 5-diphosphate (MVAPP), producing isopentenyl diphosphate (IPP). Synthesis of IPP, an isoprenoid precursor molecule that is a critical intermediate in peptidoglycan and polyisoprenoid biosynthesis, is essential in Gram-positive bacteria (e.g., Staphylococcus,...

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Identifiers

PMID: 22734632
DOI: 10.1021/bi300591x
PMCID: PMC4227304

Genes

IPP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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