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Interlaboratory Comparison of<b><i>HER-2</i></b>Oncogene Amplification as Detected by Chromogenic and Fluorescence<b><i>in situ</i></b>Hybridization

15 Jul 2004

Abstract excerpt

PURPOSE: Chromogenic in situ hybridization (CISH) is a new modification of the fluorescence in situ hybridization (FISH) technique for detection of oncogene amplification in archival tumor samples. In CISH, the oncogene probe is detected using a peroxidase reaction, allowing use of transmitted light microscopy. We compared detection of HER-2/neu amplification by CISH with a Food and Drug Administration-approved...

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PMID: 15269154
DOI: 10.1158/1078-0432.ccr-0428-03

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