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Article

Genetic polymorphisms in ABCB1 influence the pharmacodynamics of tacrolimus.

Therapeutic drug monitoring - 1 Aug 2013

Vafadari Ramin, Bouamar Rachida, Hesselink Dennis A, Kraaijeveld Rens, van Schaik Ron H N, Weimar Willem, Baan Carla C, van Gelder Teun

Abstract excerpt

INTRODUCTION: Tacrolimus has a large interindividual pharmacokinetic variability, and quantification of its effect is difficult. It is a substrate of ABCB1, an efflux pump expressed more on CD8 T cells than on CD4 T cells. The ABCB1 3435C>T single-nucleotide polymorphism (SNP) has been associated with interindividual differences in ABCB1 activity and may influence drug efficacy. Here the influence of this SNP on...

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Identifiers

PMID: 23743668
DOI: 10.1097/FTD.0b013e31828c1581

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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