Article
Glycoform remodeling generates a synthetic T cell phenotype.
Bioconjugate chemistry - 19 Jun 2013
Zou Chunxia, Loka Ravi S, Zhang Yi, Cairo Christopher W
Abstract excerpt
The glycan of specific proteins can dictate the response of cells to stimuli, and thus their phenotype. We describe a chemical strategy to modify the cellular glycoform of T cells, which resulted in a modified cellular response. Our data indicate that chemical modification of the phosphatase CD45 is responsible for the observed differences in response to receptor cross-linking. By increasing the content of...
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