Article
New susceptibility locus for obesity and dyslipidaemia on chromosome 3q22.3.
Human genomics - 5 Jun 2013
Alshahid Maie, Wakil Salma M, Al-Najai Mohammed, Muiya Nzioka P, Elhawari Samar, Gueco Daisy, Andres Editha, Hagos Samia, Mazhar Nejat, Meyer Brian F, Dzimiri Nduna
Abstract excerpt
BACKGROUND: The muscle Ras (MRAS) gene resides on chromosome 3q22.3 and encodes a member of the membrane-associated Ras small GTPase proteins, which function as signal transducers in multiple processes including cell growth and differentiation. Its role in cardiovascular disease is not fully understood yet. In a preliminary study in heterozygous familial hypercholesterolaemia, we identified a locus linking the...
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