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Article

A novel method, the Variant Impact On Linkage Effect Test (VIOLET), leads to improved identification of causal variants in linkage regions.

European journal of human genetics : EJHG - 1 Feb 2014

Martin Lisa J, Ding Lili, Zhang Xue, Kissebah Ahmed H, Olivier Michael, Benson D Woodrow

Abstract excerpt

The Human Genome Project was expected to individualize medicine by rapidly advancing knowledge of common complex disease through discovery of disease-causing genetic variants. However, this has proved challenging. Although linkage analysis has identified replicated chromosomal regions, subsequent detection of causal variants for complex traits has been limited. One explanation for this difficulty is that...

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PMID: 23736220
DOI: 10.1038/ejhg.2013.120
PMCID: PMC3895640

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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