Article
On the analysis of sequence data: testing for disease susceptibility loci using patterns of linkage disequilibrium.
Genetic epidemiology - 1 Dec 2011
Lipman Peter J, Yip Wai-Ki, AlChawa Taofik, Ludwig Kerstin U, Mangold Elisabeth, Lange Christoph
Abstract excerpt
Despite the numerous and successful applications of genome-wide association studies (GWASs), there has been a lot of difficulty in discovering disease susceptibility loci (DSLs). This is due to the fact that the GWAS approach is an indirect mapping technique, often identifying markers. For the identification of DSLs, which is required for the understanding of the genetic pathways for complex diseases, sequencing...
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