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Article

Defective gap-junctional communication associated with imaginal disc overgrowth and degeneration caused by mutations of the dco gene in Drosophila.

Developmental biology - 1 Aug 1990

Jursnich V A, Fraser S E, Held L I, Ryerse J, Bryant P J

Abstract excerpt

The lethal(3)discs overgrown (dco) locus of Drosophila melanogaster, located on the third chromosome at cytogenetic position 100A5,6-100B1,2, is necessary for normal development and growth control in the imaginal discs of the larva. Three recessive lethal alleles (dco2, dco3, and dco18) in heteroallelic combinations and one allele (dco3) when homozygous cause the imaginal discs to continue to grow beyond the...

Topics

Alleles
Animals
Cell Communication
Chromosome Mapping
Drosophila
Female
Genes, Lethal
Intercellular Junctions
Larva
Microscopy, Electron
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oviposition

Phenotype

Source

Identifiers

PMID: 2373260
DOI: 10.1016/0012-1606(90)90090-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2373260-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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