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Article

Molecular Cloning of a Novel Bone-Forming Compound: Osteoinductive Factor

1 Jun 1990

Abstract excerpt

cDNA clones encoding osteoinductive factor (OIF) have been isolated from a bovine osteoblast library. Sequence analysis of these clones indicated that the 105-amino-acid OIF is synthesized as a larger 299-amino-acid precursor, the carboxyl terminus of which is cleaved to yield the mature protein. Northern blot analysis of bovine osteoblast mRNA revealed two OIF-specific transcripts of 1.9 and 2.4 kb. The...

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Identifiers

PMID: 2372374
DOI: 10.1089/dna.1990.9.303

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