Article
Cloning of a 2.5 kb murine bone sialoprotein promoter fragment and functional analysis of putative Osf2 binding sites.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 1999
Benson M D, Aubin J E, Xiao G, Thomas P E, Franceschi R T
Abstract excerpt
Bone sialoprotein (BSP) is an extracellular matrix protein that is intimately associated with the process of biomineralization. Osf2, a member of the Cbf/runt family of transcription factors, is required for the development of osteoblasts in vivo and has been reported to stimulate the transcription of BSP when overexpressed in mesenchymal cell lines. To investigate the role of Osf2 in BSP expression, we cloned a...
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