Article
Association between vitamin D receptor gene polymorphisms and type 1 diabetes mellitus in Iranian population.
Molecular biology reports - 1 Feb 2012
Mohammadnejad Zahra, Ghanbari Mohsen, Ganjali Rashin, Afshari Jalil Tavakkol, Heydarpour Mahyar, Taghavi Seyed Morteza, Fatemi Sedigheh, Rafatpanah Houshang
Abstract excerpt
Type 1 diabetes mellitus (T1DM) is one of the T-cell mediated autoimmune diseases and vitamin D suppresses activation of T-cell and has immunomodulatory effects. In this study the association between four vitamin D receptor (VDR) gene polymorphisms, at positions FokI, BsmI, ApaI and TaqI, and susceptibility to T1DM was investigated. We assessed 87 Iranian patients with T1DM and one hundred healthy controls with...
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