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MHC class I A region diversity and polymorphism in macaque species.

Immunogenetics - 1 May 2007

Otting Nel, de Vos-Rouweler Annemiek J M, Heijmans Corrine M C, de Groot Natasja G, Doxiadis Gaby G M, Bontrop Ronald E

Abstract excerpt

The HLA-A locus represents a single copy gene that displays abundant allelic polymorphism in the human population, whereas, in contrast, a nonhuman primate species such as the rhesus macaque (Macaca mulatta) possesses multiple HLA-A-like (Mamu-A) genes, which parade varying degrees of polymorphism. The number and combination of transcribed Mamu-A genes present per chromosome display diversity in a population of...

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Identifiers

PMID: 17334754
DOI: 10.1007/s00251-007-0201-2
PMCID: PMC1914291

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