Article
Multiple variants aggregate in the neuregulin signaling pathway in a subset of schizophrenia patients.
Translational psychiatry - 28 May 2013
Hatzimanolis A, McGrath J A, Wang R, Li T, Wong P C, Nestadt G, Wolyniec P S, Valle D, Pulver A E, Avramopoulos D
Abstract excerpt
Despite the strongly held view that schizophrenia (SZ) shows substantial genetic heterogeneity, pathway heterogeneity, as seen in cancer where different pathways are affected in similar tumors, has not been explored. We explore this possibility in a case-only study of the neuregulin signaling pathway (NSP), which has been prominently implicated in SZ and for which there is detailed knowledge on the ligand- and...
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