Association of β-Secretase Functional Polymorphism with Risk of Schizophrenia.

doi:10.1089/gtmb.2016.0262

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Article

Association of β-Secretase Functional Polymorphism with Risk of Schizophrenia.

Genetic testing and molecular biomarkers - 1 Apr 2017

Rahimi-Aliabadi Simin, Shahmohammadibeni Neda, Jamshidi Javad, Shandiz Ehsan Esmaili, Mirfakhraie Reza, Ohadi Mina, Nejad Farhad Ramezani, Mansoori Nader, Taheri Mohammad, Gholipour Fatemeh, Moudi Susan, Tayebi Gouya, Divsalar Shahram, Darvish Hossein, Movafagh Abolfazl

Abstract excerpt

AIM: The NRG1-ERBB4 neurotransmitter signaling pathway plays a key role in the pathogenesis of schizophrenia (SZ). The intronic single-nucleotide polymorphism rs707284 in ERBB4 links to PI3K-AKT suppression in SZ. Another protein indirectly affecting NRG1-ERBB4 signaling is β-secretase, which is encoded by the BACE1 gene, and activates NRG1 by proteolytic cleavage. In this study, we aimed to investigate the...

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Identifiers

PMID: 28384043
DOI: 10.1089/gtmb.2016.0262

Genes

ERBB4
NRG1
BACE1

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