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Article

A model of the membrane-bound cytochrome b5-cytochrome P450 complex from NMR and mutagenesis data.

The Journal of biological chemistry - 26 Jul 2013

Ahuja Shivani, Jahr Nicole, Im Sang-Choul, Vivekanandan Subramanian, Popovych Nataliya, Le Clair Stéphanie V, Huang Rui, Soong Ronald, Xu Jiadi, Yamamoto Kazutoshi, Nanga Ravi P, Bridges Angela, Waskell Lucy, Ramamoorthy Ayyalusamy

Abstract excerpt

Microsomal cytochrome b5 (cytb5) is a membrane-bound protein that modulates the catalytic activity of its redox partner, cytochrome P4502B4 (cytP450). Here, we report the first structure of full-length rabbit ferric microsomal cytb5 (16 kDa), incorporated in two different membrane mimetics (detergent micelles and lipid bicelles). Differential line broadening of the cytb5 NMR resonances and site-directed...

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Identifiers

PMID: 23709268
DOI: 10.1074/jbc.M112.448225
PMCID: PMC3724662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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