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Article

Sulfadiazine resistance in Toxoplasma gondii: no involvement of overexpression or polymorphisms in genes of therapeutic targets and ABC transporters.

Parasite (Paris, France) - 1 Jan 2013

Doliwa Christelle, Escotte-Binet Sandie, Aubert Dominique, Sauvage Virginie, Velard Frédéric, Schmid Aline, Villena Isabelle

Abstract excerpt

Several treatment failures have been reported for the treatment of toxoplasmic encephalitis, chorioretinitis, and congenital toxoplasmosis. Recently we found three Toxoplasma gondii strains naturally resistant to sulfadiazine and we developed in vitro two sulfadiazine resistant strains, RH-R(SDZ) and ME-49-R(SDZ), by gradual pressure. In Plasmodium, common mechanisms of drug resistance involve, among others,...

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Identifiers

PMID: 23707894
DOI: 10.1051/parasite/2013020
PMCID: PMC3718540

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