Article
Sulfadiazine resistance in Toxoplasma gondii: no involvement of overexpression or polymorphisms in genes of therapeutic targets and ABC transporters.
Parasite (Paris, France) - 1 Jan 2013
Doliwa Christelle, Escotte-Binet Sandie, Aubert Dominique, Sauvage Virginie, Velard Frédéric, Schmid Aline, Villena Isabelle
Abstract excerpt
Several treatment failures have been reported for the treatment of toxoplasmic encephalitis, chorioretinitis, and congenital toxoplasmosis. Recently we found three Toxoplasma gondii strains naturally resistant to sulfadiazine and we developed in vitro two sulfadiazine resistant strains, RH-R(SDZ) and ME-49-R(SDZ), by gradual pressure. In Plasmodium, common mechanisms of drug resistance involve, among others,...
Topics
- ATP-Binding Cassette Transporters
- Animals
- Antiprotozoal Agents
- Base Sequence
- Chlorocebus aethiops
- Dihydropteroate Synthase
- Drug Resistance
- Gene Expression Regulation
- Genotype
- Molecular Sequence Data
- Phenotype
- Polymorphism, Genetic