Article
Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes.
Molecular and cellular endocrinology - 15 Aug 2013
Taneera Jalal, Fadista Joao, Ahlqvist Emma, Zhang Mengze, Wierup Nils, Renström Erik, Groop Leif
Abstract excerpt
Microarray gene expression data were used to analyze the expression pattern of cyclin, cyclin-dependent kinase (CDKs) and cyclin-dependent kinase inhibitor (CDKIs) genes from human pancreatic islets with and without type 2 diabetes (T2D). Of the cyclin genes, CCNI was the most expressed. Data obtained from microarray and qRT-PCR showed higher expression of CCND1 in diabetic islets. Among the CDKs, CDK4, CDK8 and...
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