Article
Association between DBH 19 bp insertion/deletion polymorphism and cognition in first-episode schizophrenic patients.
Schizophrenia research - 1 Jul 2013
Hui Li, Zhang Xuan, Yu Ya Qin, Han Mei, Huang Xu Feng, Chen Da Chun, Wang Zhi Ren, Du Wei Li, Kou Chang Gui, Yu Qiong, Kosten Thomas R, Zhang Xiang Yang
Abstract excerpt
Many genes associated with dopamine (DA) and norepinephrine (NE) systems influence cognitive deficits of schizophrenia patients, but one key enzyme is dopamine beta-hydroxylase (DBH), which converts DA to NE and whose activity and levels are under strong genetic control. This study examines the association of the 19 bp insertion/deletion (Ins/Del) polymorphism in the 5' flank of the DBH gene with cognitive...
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