Article
Structural and mechanistic basis of anti-termination of Rho-dependent transcription termination by bacteriophage P4 capsid protein Psu.
Nucleic acids research - 1 Aug 2013
Ranjan Amitabh, Sharma Savita, Banerjee Ramanuj, Sen Udayaditya, Sen Ranjan
Abstract excerpt
The conserved bacterial transcription terminator, Rho, is a potent target for bactericidal agents. Psu, a bacteriophage P4 capsid protein, is capable of inducing anti-termination to the Rho-dependent transcription termination. Knowledge of structural and mechanistic basis of this anti-termination is required to design peptide-inhibitor(s) of Rho from Psu. Using suppressor genetics, cross-linking, protein...
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