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Article

Tumor derived mutations of protein tyrosine phosphatase receptor type k affect its function and alter sensitivity to chemotherapeutics in glioma.

PloS one - 1 Jan 2013

Agarwal Supreet, Al-Keilani Maha S, Alqudah Mohammad A Y, Sibenaller Zita A, Ryken Timothy C, Assem Mahfoud

Abstract excerpt

Poor prognosis and resistance to therapy in malignant gliomas is mainly due to the highly dispersive nature of glioma cells. This dispersive characteristic results from genetic alterations in key regulators of cell migration and diffusion. A better understanding of these regulatory signals holds promise to improve overall survival and response to therapy. Using mapping arrays to screen for genomic alterations in...

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Source

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Identifiers

PMID: 23696788
DOI: 10.1371/journal.pone.0062852
PMCID: PMC3656086

Genes

PTPRK
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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