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Article

Downregulated HDAC3 or up-regulated microRNA-296-5p alleviates diabetic retinopathy in a mouse model

18 May 2022

Abstract excerpt

Objective: It has been demonstrated the efficacy of histone deacetylase 3 (HDAC3) in diabetes. Nevertheless, the function of HDAC3 in diabetic retinopathy (DR) remained largely obscure. Here, we investigated the HDAC3 effects in DR mice through the microRNA (miR)-296-5p/G protein subunit alpha i2 (GNAI2) axis. Methods: The mice diabetes model was established. HDAC3, GNAI2 and miR-296-5p levels in retina tissues...

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Share to Histone Deacetylase Inhibitors Research
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Identifiers

PMID: 35619945
DOI: 10.1016/j.reth.2022.04.002

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