Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of atherosclerosis susceptibility in mice with genetic defects in platelet function.

Arteriosclerosis (Dallas, Tex.) - 1 Jan 2000

Paigen B, Holmes P A, Novak E K, Swank R T

Abstract excerpt

To determine whether platelets contribute to the development of atherosclerosis, we compared the severity of atherosclerosis in susceptible C57BL/6 mice carrying either a normal or a variant phenotype for platelet function. Five genetically distinct mutants with increased bleeding times and abnormal dense granules were used: maroon (ru-2mr), light ear (le), ruby eye (ru), beige (bg1), and pale ear (ep). After a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arteriosclerosis
Share to Blood Platelets
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Disease Susceptibility

Share to Mice, Inbred C57BL

Share to Mice, Mutant Strains

Share to Mutation

Source

Identifiers

PMID: 2369371
DOI: 10.1161/01.atv.10.4.648

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of atherosclerosis susceptibility in mice with genetic defects in platelet function.PMID 2369371Read ↗

New insights into the haemostatic function of plateletsSemantic proximity Read ↗

Genetic Modifiers of Atherosclerosis in MiceSemantic proximity Read ↗

Platelets in atherothrombosis: lessons from mouse modelsSemantic proximity Read ↗

Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models.Semantic proximity Read ↗

Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction.Semantic proximity Read ↗

Novel insights into the development of atherosclerosis in hemophilia A mouse models.Semantic proximity Read ↗

The regulation of platelet-dense granules by Rab27a in the ashen mouse, a model of Hermansky-Pudlak and Griscelli syndromes, is granule-specific and dependent on genetic background.Semantic proximity Read ↗

Chylomicronemia elicits atherosclerosis in mice--brief report.Semantic proximity Read ↗

Atheromata in an inbred strain of mice.Semantic proximity Read ↗

Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype.Semantic proximity Read ↗

Differential Impact In Vivo of Pf4-ΔCre-Mediated and Gp1ba-ΔCre-Mediated Depletion of Cyclooxygenase-1 in Platelets in Mice.Semantic proximity Read ↗

Hyperreactivity of junctional adhesion molecule A-deficient platelets accelerates atherosclerosis in hyperlipidemic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.